Imidazole has a wide range of applications and market demand continues to grow

Imidazole, 1,3-diazole, is a five-membered aromatic heterocyclic compound containing two meta-nitrogen atoms in its molecular structure. The appearance of imidazole is white or light yellow solid crystal, soluble in water, chloroform, alcohol, ether, etc., slightly soluble in benzene, and very slightly soluble in petroleum ether. Imidazole is both acidic and alkaline, and can form salts with strong bases, such as picrates, nitrates, etc.

Imidazole has a unique molecular structure. As a fine chemical raw material, imidazole is widely used in pesticides, medicines, epoxy resins, coatings, organic synthesis, rubber and other fields. In the pharmaceutical field, imidazole is the main raw material for imidazole antifungal drugs such as clobendazole, econazole, ketoconazole, and clotrimazole. In addition, imidazole can also be used to produce artificial plasma, bronchial asthma treatment drugs, hypoglycemia treatment drugs, Anti-rash agent, etc.

According to the “2022-2027 Imidazole Industry Market In-depth Research and Investment Prospect Forecast Analysis Report released by the Industrial Research Center, in recent years , my country’s imidazole industry is developing well, and product supply and demand maintain a stable growth trend. In 2021, the output of the imidazole industry will increase to more than 6.0,000 tons, the demand will be approximately 4.9,000 tons, and the market size will reach more than 200 million yuan, which is the same as in 2020. A year-on-year increase of more than 22.2%.

Domestic imidazole manufacturers include Jiangsu Kanglajia Materials, Jiangxi Jinkai Chemical, Longgu Biotechnology, Shanxi Dongjinyuan Chemical, Zhicheng Chemical Technology, etc. Overall, the number of imidazole manufacturers in my country is small, and most of them have low production capacity. There are various synthesis techniques for imidazole, including glyoxal synthesis, tartaric acid method, nitrile synthesis, bromoacetaldehyde method, o-phenylenediamine and formic acid cyclization method, etc. Among them, glyoxal synthesis and nitrile synthesis are widely used.

Imidazole is easy to generate derivatives, so there are many types of imidazole derivatives, including sulfonylimidazole, hydroxyimidazole, dimethylimidazole (2MI), diphenylimidazole (2PI), diethyltetramethylimidazole (2E4MI), etc. The generation pathways of imidazole derivatives include halogenation reaction, quaternization reaction, alkyl substitution reaction, cyanoethylation reaction, salinization, etc. Imidazole and its derivatives have good biological activities, so they have attracted much attention from researchers.

Compared with aromatic amines and aliphatic amine curing agents, imidazole curing agents have the characteristics of low toxicity, low irritation, and high biological activity. In recent years, with the continuous deepening of research, imidazole curing agents have been widely used in functional new materials and optoelectronic functions. Applications in materials and other fields are becoming more and more widespread, and the future market development prospects are broad.

Industry analysts said that as a fine chemical raw material, imidazole has a wide range of applications, mainly involving medicine, pesticides, organic synthesis, etc. In the field of imidazole, the supply and demand of the imidazole market are constantly growing, and the future development prospects of the industry are broad. There are many types of imidazole derivatives and various functions, which have attracted much attention from researchers. In the future, as research continues to deepen, the application fields of imidazole derivatives are expected to expand, which will benefit the development of the imidazole industry.