Preparation and detection methods of benzalkonium chloride_Kain Industrial Additive

Background and overview^[1]

Benzalkonium chloride is also called dimethylbenzylalkyl ammonium chloride, benzalkonium chloride, and benzalkonium chloride. Benzalkonium chloride can be used as a cationic surfactant. Benzalkonium chloride is a non-oxidizing bactericide with broad-spectrum and high-efficiency sterilization and algae killing capabilities. It can effectively control the reproduction of bacteria and algae and the growth of slime in water, and has good slime stripping effects and certain dispersion and penetration. It also has certain degreasing, deodorizing and corrosion-inhibiting effects. At present, benzyl ammonium chloride is widely used in the disinfection of circulating cooling water in factories, water in power plants, paper mills, oil well water injection systems and medical equipment. It is also used for sanitary disinfection and washing of swimming pools, laundry rooms and public places, and food industry equipment. Clean. In addition, benzalkonium chloride is also used as a leveling agent and a bactericidal and antifungal agent, softener, antistatic agent, emulsifier, and conditioner in the textile printing and dyeing industry.

Preparation^[3]

Hexadecyldimethyltertiary amine: 20 mol (5.39kg);

Benzyl chloride: 20 mol (2.53kg);

Thiocarbamide: 30 mol (2.28kg);

Ethyl acetate: 100L.

The synthesis process is as follows: Mix cetyldimethyl tertiary amine, benzyl chloride and thiourea in a glass-lined reaction kettle, add an organic solvent (the organic solvent is ethyl acetate) and completely dissolve it, then open Stir and heat the device, control the system at 85°C, and keep the reaction for 10 hours. After the reaction is complete, cool to room temperature naturally until the crystals precipitate. After the crystals are completely grown, filter them with suction, and then add the filter cake to ethyl acetate for recrystallization. After the crystallization is completed, suction filtration is performed, and the obtained crystals are vacuum-dried to constant weight under conditions of -1.5Mpa and 60°C to obtain high-purity pharmaceutical grade benzalkonium chloride monomer.

Content determination^[4]

A method for determining the content of benzalkonium chloride in disinfectant wipes by high performance liquid chromatography. First, weigh the disinfectant wipe sample; second, use acetonitrile-70mmol·L-1 ammonium acetate and glacial acetic acid as the flow Phase; three, then put the disinfectant wipe sample and 25mL of the mobile phase into the separation column. The column temperature of the separation column is 40°C, and the measurement wavelength is 262nm. The disinfectant wipe sample is extracted ultrasonically with the mobile phase for 15 minutes, vortexed for 2 minutes, and diluted; 3. After dilution and cooling, transfer the disinfectant wipe sample to a 100mL volumetric flask, dilute the volume with mobile phase, measure on the machine, quantitatively determine the content of benzalkonium chloride using the external standard method, and measure the chlorine in the disinfectant wipe sample. Compare benzalkonium chloride with benzalkonium chloride standard solution.

Apply^[1-2]

Report 1,

CN201480046820.2 reports a lapping compound and a production method thereof, and more specifically relates to a lapping slurry used in industrial production applications to eliminate or minimize residues on workpieces and grinding equipment. , compound or gel. In one embodiment, the abrasive composition may comprise a superabrasive material; and a cationic surfactant or cationic polymer, wherein the cationic surfactant or cationic polymer is adsorbed on the surface of the superabrasive material. The cationic surfactant may be at least one of alkyl quaternized ammonium salts, alkyl amines and amine salts. The cationic polymer may include at least one of a quaternary ammonium salt polymer or a polyelectrolyte. The alkyl quaternized ammonium salt may include at least one of a chloride salt, a methosulfate salt, or a bromide salt. For example, the chloride salt may include stearyldimethylbenzyl ammonium chloride, cetyltrimethylammonium chloride, behenyltrimethylammonium chloride, benzalkonium chloride, cinnamonamide cocotrimonium chloride, cocotrimonium chloride, hexadecyldimethylammonium chloride, cocotrimonium chloride, hydrogenated palmitrimmonium chloride , at least one of lauryltrimethylammonium chloride, quaternary ammonium salt-15, quaternary ammonium salt-22, and quaternary ammonium salt-82. Alkyl amines or amine salts may include stearamidopropyldimethylamine lactate, stearamidopropyldimethylamine citrate, stearamidopropyldimethylamine propionate, isostearamidopropyl At least one of dimethylamine, isostearamidopropylmorpholine, wheatgermamidepropyldimethylamine and behanamidopropyldimethylamine.

Report 2,

CN98805499.X provides improved drug treatments and drugs that can be used to quickly and safely eliminate HIV and other microbial infections. The inexpensive drug can be self-administered and kept for a specified time. This excellent medicine contains antimicrobial concentrates containing microbial inhibitors, phytochemicals or isolates. Ideally, the effective medicament contains a surfactant and an aqueous carrier or solvent as well as nutrients. In a preferred form, the medicament contains: Echinacea and Myrrh phytochemicals, benzalkonium chloride, sterile aqueous solution and folic acid.

References

[1] [Chinese invention] CN201480046820.2 Grinding slurry with cationic surfactant

[2] CN98805499.X Antimicrobial prevention and treatment of human immunodeficiency virus and other infectious diseases

[3] [China invention, China invention authorization] CN201710182496.2 Benzalkonium chloride monomer synthesis process

[4]CN201210490200.0 A method for determining the content of benzalkonium chloride in disinfectant wipes by high performance liquid chromatography