Background and overview[1][2]
Phenylethyl malonate diethyl ester can be used as a pharmaceutical and chemical synthesis intermediate. If diethyl phenylethyl malonate is inhaled, move the patient to fresh air; if there is skin contact, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell; if In case of eye contact, separate eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse mouth immediately, do not induce vomiting, and seek medical attention immediately.
Function and use[1-6]
Phenylethyl malonate diethyl ester can be used as a pharmaceutical and chemical synthesis intermediate. Examples of its application are as follows:
1. Prepare an insect-proof, high-temperature-resistant and flame-retardant cable,
Includes the following ingredients in parts by weight: 40-50 parts of styrene-butadiene rubber, 30-40 parts of nitrile rubber, 10-14 parts of calcium stearate, 3-8 parts of nanometer talc, and 1-4 parts of magnesium silicide , 8-15 parts of methacrylate, 7-10 parts of montmorillonite, 5-9 parts of fenvalerate, 4-8 parts of enethrin, 6-10 parts of isosorbide dinitrate, phenylethyl Diethyl malonate 9-13 parts, acetyl tributyl citrate 5-12 parts, Cetrimonium p-toluenesulfonate 10-15 parts. This cable product has good high temperature resistance and high flame retardant properties, and has a good control effect on insects and ants.
2. Preparation of a new anti-wrinkle and color-preserving finishing agent,
Includes the following components by weight: 15-23 parts of polyoxyethylene sorbitan fatty acid ester, 5-10 parts of polyethylene glycol oleyl ether, 1-5 parts of sodium polyacrylate, polypropylene resin 8-15 parts, dimethylformamide 3-10 parts, epichlorohydrin 8-16 parts, diethyl phenylethylmalonate 20-28 parts, N-benzyloxycarbonyl-6-aminocaproic acid 12-17 parts, potassium diclofenac 2-9 parts, thiourea 4-12 parts. This finishing agent can significantly improve the anti-wrinkle performance of cotton fabrics, while maintaining its original luster and feel, and avoiding the reduction in wearing comfort caused by anti-wrinkle treatment.
3. Preparation of water-based melamine paint with aging resistance, water resistance, and oil resistance,
The water-based melamine paint includes the following parts by weight of raw materials: aging resistance, water resistance, oil resistance water-based melamine paint, which is composed of: 26 parts of modified polyimide resin solution, 12 parts of gray calcium powder, 8 parts of calcite powder, 7 parts of titanium dioxide, 3 parts of bentonite, 6.6 parts of airgel insulation particles, 1.2 parts of nano aluminum oxide, 0.2 parts of water-based defoaming agent, 0.4 parts of alkali swelling thickener, 90 parts of water , 0.1 to 0.4 parts of diethyl phenylethyl malonate, 0.5 parts of tetramethylethylene glycol, 0.2 parts of trishydroxymethylaminomethane and 0.2 parts of synergist 3-cyclopentylpropionyl chloride; the present invention is obviously The aging resistance, water resistance, and oil resistance of melamine paint are improved, and it is not easy to crack and powder.
4. Preparation of a nitrogen-based composite flame retardant,
The nitrogen-based composite flame retardant is composed of flame retardant particles, and the flame retardant particles include an inner core and a surface layer; the inner core includes 1.5wt%~2wt% N-tert-butylbenzylamine, 0.35wt %~0.5wt% B-butyrolactone, 5wt%~10wt% ethyl p-methoxyphenylacetate, 3.5wt%~5wt% 1,4,5,8-naphthalenetetracarboxylic anhydride, 1.5wt% ~2.5wt% 4-bromo-3-methoxyphenol, 0.5wt%~1wt% 2,5-dibromoterephthalic acid; the surface layer includes 3.5wt%~5wt% chlorinated isothiocyanate Ethyl ester, 1.7wt%~2wt% diethyl phenylethylmalonate, 0.15wt%~0.2wt% 3-thiocyanatopropyltriethoxysilane, 5.5wt%~8wt% 4 -Chloromethyl-2-methylthiazole hydrochloride, 4wt%~5.5wt% 4-methoxytetrafluorobenzyl bromide, 3wt%~4.5wt% lauryl alcohol sulfoacetate sodium salt. The invention also provides a method for preparing the above flame retardant. The invention can solve the deficiencies of the prior art and reduce the impact on the physical properties of the added base material while maintaining the flame retardant effect.
5. Preparation of modified fly ash for cross-linked polyethylene insulated cable materials,
It is made of the following raw materials by weight: fly ash 100, porcelain calcium 25-35, polycarbonate 1,6-hexanediol 5-7, zirconium phosphate 15-20, wool wax 4 -6. Cetyldimethylethylammonium bromide 1-2, phenylethylmalonate diethyl ester 5-10, copper thiocyanate 1.5-2.5, dimethylaminoethyl acrylate 2- 4. Lithium stearate 1.5-2.5, basic lead carbonate 2-3, N-(βaminoethyl)-γ-aminopropylmethyl-dimethoxysilane 1-2, 3,5-di-tert Butyl-4-hydroxybenzoic acid cetyl ester 0.5-1, additive 2.5-4.5. The modified fly ash of the present invention can improve the tensile strength and elongation at break of the polyethylene composite material, reduce the thermal expansion coefficient and shrinkage rate, improve the dimensional stability and heat resistance of the product, have significant filling effect, high application value, and completely It meets the technical requirements of plastic fillers and has broad market prospects.
6. Preparation of primidone,
Primidone tablets are a commonly used anti-epileptic drug. It is clinically used for the treatment of tonic-clonic seizures (grand mal seizures) of epilepsy, essential tremor and senile tremor, but is not used as a first-line drug. Consider using them only when phenytoin, phenobarbital, and carbamazepine are ineffective alone or in combination. This drug will be more effective if combined with phenytoin sodium. Deoxyphenobarbital has poor efficacy in treating petit mal seizures, but is effective in treating myoclonus in young children. This drug can also be used to treat prolonged Q-T syndrome, hemifacial spasm, restless legs syndrome, and benign familial tremor.
The specific steps of the preparation method are as follows: (1) using diethyl phenylethyl malonate and thiourea as raw materials, synthesizing sodium thiophenobarbital through condensation; (2) thiophenobarbital Thiophenbarbital is synthesized by acidification with sodium thiol; (3) thiophenobarbital is subjected to high-pressure hydrogenation and reduction using low-carbon alcohol as the solvent and palladium carbon as the catalyst to obtain primidone; its preparation route is as follows:The advantage of the present invention is that on the basis of the original process, the synthesis process is optimized to avoid the need to use a large amount of acid in the reduction process, thereby avoiding environmental pollution.
7. Preparation of a high-leveling polyester resin,
It is formed by copolymerization of diethyl phenylethyl malonate, citric acid monoester compound, diglycolic acid, thiodiglycol, octyloxyglycerol, neopentyl glycol, and hexahydrophthalic anhydride. The high-leveling polyester resin has soft chain segments, good melt fluidity, and low high-temperature viscosity, and can be used to prepare HAA curing system powder coatings.
Preparation
1. Obtained from diethyl phenylmalonate through ethylation. 2. Benzyl cyanide reacts with ethanol in the presence of sulfuric acid to form ethyl phenylacetate. The obtained ethyl phenylacetate is subjected to condensation reaction with diethyl oxalate and sodium ethoxide after rectification, and is then subjected to ethylation reaction with ethyl bromide after hydrochloric acid precipitation to generate diethyl phenylethyl malonate. The finished product is obtained by fractional distillation under reduced pressure. Another production method is the condensation of ethyl phenylacetate with diethyl carbonate and ethyl bromide.
Main reference materials
[1] CN201610224138.9 Preparation method of insect-proof, high-temperature-resistant and flame-retardant cable
[2] CN201810157780.9 Aging resistance, water resistance, oil resistance water-based imitation porcelain coating and preparation method thereof
[3] CN201610011786.6 A new anti-wrinkle and color-preserving finishing agent and its preparation method
[4] CN201510820836.0 A nitrogen-based composite flame retardant and its preparation method
[5] CN201410335846.0 Modified fly ash for cross-linked polyethylene insulated cable materials and preparation method thereof
[6] CN201810445015.7 A high-leveling polyester resin and its preparation method and application
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