Toluene diisocyanate manufacturer Knowledge Indomethacin Indomethacin

Indomethacin Indomethacin

Indomethacin Structural Formula

Structural formula

Business number 0164
Molecular formula C19H16ClNO4
Molecular weight 357.79
label

indomethacin,

anti-inflammatory indoleic acid,

1-p-Chlorobenzoyl-5-methoxy-2-methylindoleacetic acid,

Indenaxin,

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

Numbering system

CAS number:53-86-1

MDL number:MFCD00057095

EINECS number:200-186-5

RTECS number:NL3500000

BRN number:497341

PubChem number:24278173

Physical property data

1. Character:White crystal. Sensitive to light.


2. Density (g/mL,25/4): Undetermined


3. Relative vapor density (g/mL,AIR=1): Undetermined


4. Melting point (ºC):155162


5. Boiling point (ºC,Undetermined


6. Boiling point (ºC,5.2kPa): Undetermined


7. Refractive index: undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (º): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. 2. Molar volume (m3/mol) :269.5


3. isotonic ratio(90.2K)707.6


4. Surface Tension(dyne/cm)47.4


5. Polarizability(10-24cm3)37.49

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 4

5. Number of tautomers: none

6. Topological molecule polar surface area 68.5

7. Number of heavy atoms: 25

8. Surface charge: 0

9. Complexity: 506

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed in4Preserve dry.

Synthesis method

Indomethacin is obtained by diazotization, reduction, acidification, hydrolysis and cyclization of p-aminoanisole.

Purpose

For biochemical research. Biosynthesis of prostaglandins. The It is an anti-inflammatory product with obvious antipyretic effects. It is mainly used for rheumatic arthritis, ankylosing spondylitis, osteoarthritis, etc. that are intolerant to salicylic acid drugs or have insignificant efficacy.

“>P-aminoanisole undergoes diazotization, reduction, acidification, hydrolysis and cyclization to obtain indomethacin.

Purpose

For biochemical research. Biosynthesis of prostaglandins. The It is an anti-inflammatory product with obvious antipyretic effects. It is mainly used for rheumatic arthritis, ankylosing spondylitis, osteoarthritis, etc. that are intolerant to salicylic acid drugs or have insignificant efficacy.

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.chemicalchem.com/archives/21501

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