Toluene diisocyanate manufacturer Knowledge Methotrexate Methotrexate

Methotrexate Methotrexate

Methotrexate structural formula

Structural formula

Business number 01A4
Molecular formula C20H22N8O5
Molecular weight 454.45
label

(+)-Amethopterin,

4-Amino-10-methylfolic acid,

4-Amino-N10-methylpteroyl-L-glutamic acid,

Antifolan,

Methylaminopterin,

MTX

Numbering system

CAS number:59-05-2

MDL number:MFCD00064370

EINECS number:200-413-8

RTECS number:MA1225000

BRN number:70669

PubChem number:24897373

Physical property data

1. Characteristics: yellow crystal. Odorless.


2. Density (g/mL,25/4℃): Undetermined


3. Relative vapor density (g/mL,air=1): Undetermined


4. Melting point (ºC): Undetermined


5. Boiling point (ºC,Normal pressure): Undetermined


6. Boiling point (ºC,5.2kPa): Undetermined


7. Refractive index: Undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (º): SPAN>Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa,25ºC9. Complexity: 704


10. Number of isotope atoms: 0


11. Determine the number of atomic stereocenters: 1


12. The number of uncertain atomic stereocenters: 0


13. Determine the number of stereocenters of chemical bonds: 0


14. Uncertain number of chemical bond stereocenters: 0


15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

Sealing4Store dry at ℃.

Synthesis method

By2,4,5,6- It is obtained by cyclizing tetraaminopyrimidine with dibromopropionaldehyde and then condensing it with p-methylaminobenzoylglutamic acid.

Purpose

Folic acid antagonizes Liu. A potent inhibitor of dihydrofolate reductase. Immunosuppressants. Tissue culture reagents.


This product is a good anti-tumor drug, used for acute lymphoblastic leukemia, lymphoma, malignant mole, choriocarcinoma, and squamous epithelium cancer, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc. Oral methotrexate12hAfter the original drug90%Excreted in urine, the main metabolite is7-Hydroxymethotrexate. Intravenous injection in ratsLD50 for14mg/kg.

font-family: Arial; mso-bidi-font-family: Arial; mso-font-kerning: 0pt”>,4,5,6-It is obtained by cyclizing tetraaminopyrimidine with dibromopropionaldehyde and then condensing it with p-methylaminobenzoylglutamic acid.

Purpose

Folic acid antagonizes Liu. A potent inhibitor of dihydrofolate reductase. Immunosuppressants. Tissue culture reagents.


This product is a good anti-tumor drug, used for acute lymphoblastic leukemia, lymphoma, malignant mole, choriocarcinoma, and squamous epithelium cancer, lung cancer, cervical cancer, breast cancer and osteosarcoma, etc. Oral methotrexate12hAfter the original drug90%Excreted in urine, the main metabolite is7-Hydroxymethotrexate. Intravenous injection in ratsLD50 for14mg/kg.

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.chemicalchem.com/archives/22808

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