Application of 3-thiophenylboronic acid_Kain Industrial Additive

Background and overview^[1]

3-Thiophenylboronic acid is a derivative of phenylboronic acid and can be used as a pharmaceutical synthesis intermediate. In addition, phenylboronic acid-functionalized magnetic nanoparticles with protective groups can specifically bind carbohydrates, effectively remove non-specific interference substances such as proteins and peptides, and quickly and sensitively detect low-abundance carbohydrate samples. Perform analysis.

Structure

Apply^[1]

1) 3-Thiophenylboronic acid is used for the preparation of collector in the calcination process of high-purity quartz sand. The collector is prepared according to the following scheme: according to the mass parts, 12 parts of 4- Diphenylamine sulfonic acid, 11 parts of industrial oleic acid, 0.04 parts of 3-thiophenylboronic acid, 0.05 parts of polyaminopropyl biguanide stearate, 0.05 parts of polymethyleneoxybicyclooxazolidine, 2 Add 0.3 parts of methyl eugenol PEG-8 polydimethylsiloxane, 0.3 parts of 2-(thiophene-2-carbonyl)benzoic acid and 65 parts of ethanol into the reaction kettle, stir to dissolve, and control the temperature 55℃, adjust the pH value of the system to 9 with sodium hydroxide solution, react for 34 minutes, then filter the solution, evaporate the solvent in the filtrate to dryness, add 7 parts of pentaxanthate and 0.5 parts of dodecyl Sodium benzenesulfonate, stir and mix for 40 minutes to obtain a collector.

2) 3-Thiophenylboronic acid can be used to prepare phenylboronic acid-functionalized magnetic nanoparticles with protective groups, wherein the phenylboronic acid-functionalized magnetic nanoparticles with protective groups include magnetic Nanoparticles and phenylboronic acid functional groups and protective groups modified on their surfaces; wherein, the magnetic nanoparticles are silica-doped magnetic nanoparticles with active groups modified on the surface; the protective groups are A protective molecule with a hydroxyl group at the end. The magnetic nanoparticles are preferably superparamagnetic ferroferric oxide magnetic nanoparticles.

The phenylboronic acid functional group is provided by a phenylboronic acid derivative, which can be selected from a wide range. For example, it can be phenylboronic acid with an active modifiable group, preferably , the phenylboronic acid with an active modifiable group is selected from one or more of carboxyphenylboronic acid, aminophenylboronic acid or mercaptophenylboronic acid. More preferably, the phenylboronic acid with an active modifiable group The boric acid is selected from the group consisting of 2-aminophenylboronic acid, 2-carboxyphenylboronic acid, 3-mercaptophenylboronic acid, 3-aminophenylboronic acid, 3-hydroxyphenylboronic acid, 3-carboxyphenylboronic acid, 4-mercaptophenylboronic acid, and 4-aminophenylboronic acid. , one or more of 4-hydroxyphenylboronic acid, 4-carboxyphenylboronic acid and 4-(trans-2-carboxyvinyl)phenylboronic acid.

Main reference materials

[1] CN201810655277.6 A method for calcining high-purity quartz sand

[2] CN201810655277.6 A method for calcining high-purity quartz sand