Structural formula
Business number | 01W9 |
---|---|
Molecular formula | C10H8N2O3 |
Molecular weight | 204.18 |
label |
None yet |
Numbering system
CAS number:85-81-4
MDL number:MFCD00006802
EINECS number:201-633-7
RTECS number:VC0365000
BRN number:None
PubChem number:24852410
Physical property data
1. Character: yellow needle crystal
2. Density (g/mL ,25/4℃): Undetermined
3. Relative vapor density (g/mL,Air=1): Undetermined
4. Melting point (ºC):159-160℃
5. Boiling point (ºC,Normal pressure): Undetermined
6. Boiling point (ºC,5.2 kPa): Undetermined
7. Refractive Index: Undetermined
8. Flash point (ºC): Undetermined
9. Specific optical rotation (º ): Undetermined
10. Autoignition point or ignition temperature (ºC): Undetermined
11. Vapor pressure (kPa, 25ºC): Undetermined
12. Saturated vapor pressure (kPa ,60ºC): Undetermined
3. isotonic specific volume (90.2K):417.4
4. Surface Tension (dyne/cm):55.9
5. Polarizability(10-24cm3):21.96
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 0
3. Number of hydrogen bond acceptors: 4
4. Number of rotatable chemical bonds: 1
5. Number of tautomers: none
6. Topological molecule polar surface area 67.9
7. Number of heavy atoms: 15
8. Surface charge: 0
9. Complexity: 241
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 0
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
Sealed at4℃Save in a dry place and away from light.
Synthesis method
By4-methoxy-2-Nitroaniline is obtained by cyclization reaction. Add glycerol into the reaction pot and heat at 70℃Add sulfuric acid below and then put in4-Methoxy-2-Nitroaniline. at75-80℃After insulating, add an aqueous solution of potassium iodide and iodine, and raise the temperature to 125℃, and keep warm until the reaction reaches the end point. Dilute with ice water and incubate at 35℃The following is neutralized with sodium hydroxide solution pH The value is3.5, filter, wash to pHValue is 5, got6-Methoxy-8-nitroquinoline. The yield is 90%.
Purpose
This product can be used as an intermediate for the antimalarial drug primaquine phosphate.
y: Arial; mso-hansi-font-family: Arial; mso-bidi-font-family: Arial”>Add sulfuric acid below and then put in4-Methoxy-2-Nitroaniline .At75-80℃After insulating, add an aqueous solution of potassium iodide and iodine, and raise the temperature to 125℃, incubate until the reaction reaches the end point. Dilute with ice water, in35℃Neutralize with sodium hydroxide solution belowpH The value is3.5, filter, wash to pHValue is56-Methoxy-8-nitroquinoline. The yield is 90%.
Purpose
This product can be used as an intermediate for the antimalarial drug primaquine phosphate.