Griseofulvin Griseofulvin

Structural formula

• Numbering system
• Physical property data
• Toxicological data
• Ecological data
• Molecular structure data
• Computing chemical data
• More
  • Properties and Stability
  • Storage method
  • Synthesis method
  • Purpose

Numbering system

CAS number:126-07-8

MDL number:MFCD00082343

EINECS number:204-767-4

RTECS number:WG9800000

BRN number:95226

PubChem number:24850369

Physical property data

1. Properties: white or off-white powder, odorless or almost odorless, slightly bitter taste

2. Melting point: 218-224℃

3. Specific optical rotation: +370°

4. Solubility: easily soluble in tetrachloroethane, soluble in acetone or chloroform, slightly soluble in methanol or ethanol, very slightly soluble in water

Toxicological data

None

Ecological data

None

Molecular structure data

5. Molecular property data:

1. Molar refractive index: 80.66

2. Molar volume (m³/mol):238.3

3. isotonic specific volume (90.2K):648.9

4. Surface Tension (dyne/cm):54.9

5. Polarizability（10^-24cm³):31.97

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 0

3. Number of hydrogen bond acceptors: 6

4. Number of rotatable chemical bonds: 3

5. Number of tautomers: 2

6. Topological molecule polar surface area 71.1

7. Number of heavy atoms: 24

8. Surface charge: 0

9. Complexity: 575

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 2

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

Basic properties: This product is an antibiotic that has a strong effect on killing mold on the body surface. It is stable to heat and does not decompose when exposed to heat.

Storage method

Storage: Store at room temperature.

Synthesis method

Brief description of the production method: Griseofulvin is an antibiotic extracted from the culture and fermentation broth of Penicilli-um griseofulvum.

Purpose

Usage: This product has inhibitory effects on various dermatophytes, including Epidermophyton, Dermatophyton and Microsporum. Ineffective against tinea versicolor, albicans and bacteria. This product has a bacteriostatic effect and is effective against vigorously growing fungi. This product is used for tinea capitis, onychomycosis, tinea shingles, tinea pedis and tinea corporis caused by sensitive fungi.