1. It can be divided into two categories according to the strength of its effect:
(1) Solvents with small surface tension and miscible with water, including ethanol, propylene glycol, glycerol, dimethyl sulfoxide, etc.
(2)Surfactants, such as anionic surfactants, certain polyol surfactants (Span type), polyoxyethylene surfactants (Tween type) )
2. It can be divided into three categories according to the route of administration:
(1) Wetting agents used in external preparations include surfactants and alcohols with low surface tension and miscibility with water.
(2) Wetting agents used in oral preparations include ethanol, glycerol, Tweens, etc. that have low surface tension and are miscible with water.
(3) Wetting agents for injection include ethanol, propylene glycol, glycerol, polyethylene glycol 200~400, etc. and Tween-80 that have low surface tension and are miscible with water.
3. Divided into two categories according to properties
Wetting agents are available in anionic and nonionicSurface Active agent.
Anionic surfactants include alkyl sulfates and sulfonates , fatty acids or fatty acid ester sulfates, carboxylic acid soaps, phosphate esters, etc.
Nonionic surfactants include polyoxyethylene alkyl phenol ethers , polyoxyethylene fatty alcohol ether, polyoxyethylene polyoxypropylene block copolymer, etc.
There is another category on the market The latest type of silanol nonionic surfactant, also known as wetting agent, features: low molecular weight, polyhydrophobic groups in an umbrella-shaped symmetrical structure, compared with traditional surfactants, its wetting and permeability performance is extremely excellent and efficient. It is a revolutionary new generation of surfactant. It has extremely low dynamic and static surface tension, contains dihydroxyl, reactive active agent, is chemically inert, and generally does not participate in the chemical reaction of the system. It has good acid and alkali resistance and stable chemical properties. Typical models are:GSK-588/582/585 and other series.