Barbituric acid downstream products are subject to state control, and the overall industry trend is sluggish

Barbituric acid, also known as malonyl urea and 2,4,6-pyrimidinetrione, is an organic compound with the chemical formula C4H4N2O3. Barbituric acid mainly appears as a white crystalline powder, which can react with metals to form salt compounds. In the pharmaceutical field, barbituric acid is mainly used to synthesize pharmaceutical intermediates such as amobarbital, phenobarbital, and vitamin B12; in the chemical industry, barbituric acid is used as an intermediate to synthesize plastics or benzimidazolone organic dyes. , and it is also a catalyst and analytical reagent for various polymerization reactions.

Barbituric acid was first made by German scientists through the reaction of dibromobarbituric acid and hydrogen cyanide. The industry as a whole started early, and now it has formed a relatively mature production process. At present, the mainstream production process on the market is to prepare barbituric acid through the condensation reaction of diethyl malonate and urea catalyzed by sodium ethoxide. Some companies also use enzymatic conversion methods that are simple to operate and have low production costs. Acid production.

Barbituric acid itself has no pharmacological effects, but its derivatives, barbiturates, have sedative, hypnotic, and anesthetic effects. They are a type of sedative that acts on the central nervous system. Barbiturates can also be used as anxiolytics, hypnotics, and antispasmodics, and are widely used in the medical field.

According to the “2023-2028 China Barbituric Acid Industry Market In-depth Research and Development Prospects Forecast Report released by the Industrial Research Center , there are a wide variety of barbiturates, including alobarbital, amobarbital, apubarbital, phenolbarbital, secobarbital, etc. Barbiturates are prone to tolerance and addiction, and long-term use may cause drug efficacy decline, drug dependence, and may also cause allergies, hinder the effects of other drugs, and other adverse reactions. Therefore, barbiturates are currently used to treat sleep disorders. In the clinical treatment of diseases such as depression and anxiety, benzodiazepines, which have similar efficacy but are relatively safe, are often used instead of barbiturates. Barbiturates are also included in the national list of secondary controlled drugs. Even though barbiturates are still difficult to replace in anti-epilepsy and general anesthesia and have certain market demand, the development of the barbituric acid industry is relatively sluggish due to the influence of national policies. In 2022, my country’s barbituric acid market size will be only 35 million yuan.

There are few barbituric acid production companies in my country, and the market concentration is low. Small manufacturers are the main manufacturers, and competition has eased. The main companies include Shandong Xinhua Pharmaceutical, Zhengzhou Lifeng Chemical, Hebei Xingding Chemical, etc.

The application of barbituric acid has attracted academic attention. Many research institutions such as Henan University, Northwest Normal University, Sichuan University, and Shenyang Institute of Applied Experiments of the Chinese Academy of Sciences all have barbituric acid research patents. Industry analysts said that my country’s barbituric acid industry is currently greatly affected by policies and the market sentiment is low. Barbituric acid Producers can cooperate with research institutions to increase research efforts, explore the application value of barbituric acid in different fields, expand barbituric acid application channels, and inject vitality into the industry.