2-Chloropropionyl chloride is mainly used to produce ibuprofen API. Market demand is greatly affected by the ibuprofen industry.

2-Chloropropionyl chloride, also known as 2-chloropropionyl or 2-chloropropionyl chloride, α-chloropropionyl chloride, D-2-chloropropionyl chloride, appears as a colorless or light yellow liquid, and its chemical formula is C3H4Cl2O. The molecular weight is 126.97 and the CAS number is 7623-09-8. It is an important chemical and pharmaceutical intermediate and can be used to produce ibuprofen, loxoprofen sodium API and propionamide herbicides.

There are many synthetic process routes for 3-chloropropionyl chloride, including the three-step synthesis of 1,2-dichloropropane, the chlorination of propionyl chloride, the one-step method of L-lactic acid and dithionyl chloride, and the chlorination of 2-chloropropionic acid. Among them, the three-step synthesis method of 1,2-dichloropropane uses 1,2-dichloropropane, chlorine gas, and anhydrous aluminum trichloride as the main raw materials; the propionyl chloride chlorination method uses propionyl chloride, chlorine gas, and chlorosulfonic acid as the main raw materials. Raw materials: L-lactic acid and thionyl chloride. The one-step method uses L-lactic acid and thionyl chloride as raw materials.

2-Chloropropionyl chloride is mainly used in the pharmaceutical field to produce ibuprofen API. Relevant users include Shandong Xinhua Pharmaceutical Co., Ltd., Hubei Hendy Pharmaceutical Co., Ltd., and SI GROUP of the United States. , BASF of Germany, SOLARA of India, IOL of India and other companies. In 2022, the application demand for 2-chloropropionyl chloride in the domestic pharmaceutical field will account for 96.1%. my country is the main producer of ibuprofen API. In recent years, domestic demand for ibuprofen preparations has continued to grow, driving the output of the ibuprofen API industry to continue to increase, laying the foundation for the growth of domestic 2-chloropropionyl chloride market demand. In 2022, my country’s 2-chloropropionyl chloride industry demand will exceed 10,000 tons.

According to the“2023-2027 2-chloropropionyl chloride industry in-depth market research and investment strategy recommendations report” released by the Industrial Research Center Since 2-chloropropionyl chloride is currently mainly used to produce ibuprofen raw materials, the market capacity is relatively limited. There are not many 2-chloropropionyl chloride manufacturers in my country. Representative companies include Xinhua Pharmaceutical (Shouguang) Co., Ltd., Guangrao County Dongxing Chemical Co., Ltd., Jingmen Qiangsheng Chemical Co., Ltd., Inner Mongolia Huichang Industrial Co., Ltd. Among them, Xinhua Pharmaceutical (Shouguang) Co., Ltd. is a subsidiary of Shandong Xinhua Pharmaceutical Co., Ltd., with large production capacity of 2-chloropropionyl chloride, good product quality, and strong market competitiveness in the domestic market.

Industry analysts said that the development of the 2-chloropropionyl chloride industry is greatly affected by the ibuprofen API and its preparation industry. Currently, ibuprofen sustained-release capsules and ibuprofen granules are included in the third batch of national centralized procurement, and ibuprofen tablets and ibuprofen injection are included in the fourth batch of national centralized procurement. Driven by the drug centralized procurement policy, the prices of ibuprofen sustained-release capsules, ibuprofen granules, ibuprofen tablets and ibuprofen injection are expected to continue to decrease. Domestic patients are more interested in ibuprofen sustained-release capsules, ibuprofen granules. The demand for ibuprofen tablets, ibuprofen tablets and ibuprofen injection may further increase, thereby driving the growth of domestic ibuprofen raw material production and providing a driving force for the development of the 2-chloropropionyl chloride demand market.