Dimethyl fumarate (DMF) has excellent performance and the industry development trend continues to improve.

Dimethyl fumarate (DMF), also known as dimethyl fumarate and dimethyl fumarate, is a chemical substance with the molecular formula C6H8O4. Dimethyl fumarate appears as white crystals or crystalline powder with a pungent smell. It is soluble in acetone, ethyl ester and chloroform, but insoluble in water. Dimethyl fumarate has the characteristics of stable chemical properties and broad-spectrum antibacterial properties, and has broad application prospects in agricultural and forestry products, food processing, medicine and other fields.

The production methods of dimethyl fumarate include four methods: maleic anhydride hydrolysis isomerization, fumaric acid esterification, furfural oxidative esterification and maleic acid isomerization. The fumaric acid esterification method is widely used in the production process of dimethyl fumarate. This method uses fumaric acid as raw material, ferric chloride hexahydrate, sulfuric acid, boron trifluoride, etc. as catalysts, and undergoes an esterification reaction. The finished product is obtained. The fumaric acid esterification method has the advantages of high yield of finished products, easy manufacturing, and full utilization of raw materials, and is suitable for large-scale production.

According to the “2023-2028 China Dimethyl Fumarate (DMF) Industry Market In-depth Research and Development Prospects Forecast Report》 shows that dimethyl fumarate has excellent performance and is widely used in agricultural and forestry products, food processing, medicine, etc. In the field of agricultural and forestry products, dimethyl fumarate has broad-spectrum antibacterial characteristics and can be used as a feed antifungal agent, which can effectively inhibit the growth of mold in feed; in the field of food processing, dimethyl fumarate has been used as a food Antiseptic preservative, but due to its allergenicity and corrosiveness, it is currently not allowed to be used in food; in the medical field, dimethyl fumarate can be used to treat psoriasis, multiple sclerosis, etc.

Multiple sclerosis (MS) is an autoimmune disease with clinical manifestations such as ataxia, limb weakness, bladder dysfunction, cognitive impairment, etc. Currently, the number of patients with multiple sclerosis in my country reaches approximately 48,000. Dimethyl fumarate enteric-coated capsules are gelatin capsules containing enteric-coated mini-tablets of dimethyl fumarate for the treatment of multiple sclerosis. In January 2023, Tefeda, a dimethyl fumarate enteric-coated capsule, was successfully included in the national medical insurance directory. Against this background, the development prospects of my country’s dimethyl fumarate industry will continue to improve.

In recent years, the number of dimethyl fumarate manufacturers in my country has continued to grow, and the market competition has become fiercer. The main players in my country’s dimethyl fumarate market include Hubei Jusheng Technology Co., Ltd., Shandong Suitai Biotechnology Co., Ltd., Nanjing Bermuda Biotechnology Co., Ltd., Biogen Biotechnology (Shanghai) Co., Ltd., etc. Industry analysts said that thanks to the rapid development of the downstream industry, the market demand for dimethyl fumarate is increasingly strong. It is expected that in the future, as Chinese enterprises and related scientific research institutions continue to increase research efforts, dimethyl fumarate will gain broad application prospects in the pharmaceutical field.