Driven by technological upgrading and demand growth, the hydroxylamine hydrochloride industry has huge development potential

Hydroxylamine hydrochloride is an inorganic substance with the molecular formula HONH3Cl or NH3OHCl. It appears as a colorless crystal. It is soluble in hot water, alcohol, and glycerol, but insoluble in ether. It is highly corrosive, hygroscopic, and easy to deliquesce. At present, hydroxylamine hydrochloride in China is mainly prepared by chemical synthesis methods, including nitromethane method and sodium nitrite synthesis method. The sodium nitrite synthesis method refers to the method of preparing hydroxylamine hydrochloride using sodium nitrite, sodium metabisulfite, acetone, etc. as raw materials, through sulfuric acid acidification, liquid alkali neutralization, distillation and other links; the nitromethane method refers to the method of using nitromethane and hydrochloric acid A method for preparing hydroxylamine hydrochloride from raw materials through batch reaction.

For a long time, the mainstream method for industrial preparation of hydroxylamine hydrochloride in my country has been the nitromethane method. However, after long-term application, it has been found that this method has low product yield, long reaction time, high energy consumption, serious pollution, many low-value by-products and is difficult to produce. Separation and other issues. At present, under the background of the continuous strengthening of domestic environmental protection supervision and the continuous advancement of dual-carbon goals, the nitromethane method has been difficult to adapt to the requirements of green chemical production, bringing cost and environmental pressure to production companies. Therefore, accelerating the optimization and upgrading of technology and the development of new production methods have become the primary prerequisites for the development of my country’s hydroxylamine hydrochloride industry.

In 2018, Kairuiying Technology and the Department of Chemical Engineering of Tsinghua University jointly developed hydroxylamine hydrochloride catalytic continuous production technology. Compared with nitromethane technology, the reaction time is shortened from 48 hours to 2 hours, and the product output rate is increased from 70% to 70%. 95%, and the product purity reaches more than 99%; in 2022, Jinhua new material technology achieved new breakthroughs and developed a new green production method for hydroxylamine hydrochloride, which refers to a type of ethyl ketone that uses high-efficiency “extraction-induced polymerization-micropore filtration” to purify methyl ethyl ketone in series Compared with traditional technology, this method of preparing hydroxylamine hydrochloride from oxime has a material conversion rate of over 95%, a reduction of steam and electricity consumption rates of 50%, and zero wastewater discharge.

At present, my country’s hydroxylamine hydrochloride production technology has reached the international leading level. The leading technical advantages have laid a good foundation for the rapid development of my country’s hydroxylamine hydrochloride industry. According to the “China Hydroxylamine Hydrochloride Industry Market Monitoring and Future Development Prospects Research Report 2023-2027” released by the Industrial Research Center, In 2021, the domestic production capacity of hydroxylamine hydrochloride has exceeded 55,000 tons.

Hydroxylamine hydrochloride is an important type of chemical raw material and pharmaceutical intermediate, which is widely used in the fields of medicine, pesticides, rubber, dyes, chemical industry and other fields. In the field of medicine, hydroxylamine hydrochloride is an important raw material for the anticancer drug hydroxyurea, the sulfonamide drug sulfamethoxazole, the antibiotic cefuroxime, roxithromycin, etc.; in the field of pesticides, hydroxylamine hydrochloride is an important raw material for low-toxicity trifloxystrobin, clethodim, etc. Raw material for broad-spectrum pesticides; in the field of dyes, hydroxylamine hydrochloride is mainly used in the preparation of isatin intermediates; in the field of chemical industry, hydroxylamine hydrochloride is a reducing agent for the analysis of formaldehyde and furfural.

Industrial analysts personnel said that under the background of the continuous improvement of the technical level of domestic hydroxylamine hydrochloride enterprises and the continuous expansion of application fields, its market demand continues Increase, production capacity continues to rise. At present, my country has become one of the major producers and exporters of hydroxylamine hydrochloride in the world, and the domestic hydroxylamine hydrochloride industry has great development potential. In the future, leading domestic hydroxylamine hydrochloride companies such as Jinhua New Materials, Jiuchen New Materials, and Yinglang Chemical are expected to challenge the leading positions of foreign-funded companies such as BASF and Bayer in the global market.