There is a strong demand for the development and production of deuterium-labeled compounds, which have important uses in the medical field.

Deuterium, one of the isotopes of hydrogen, has the chemical symbol 2H or D. Its atomic weight is twice that of ordinary light hydrogen, also known as heavy hydrogen. Deuterium has a wide range of uses and can be used as an isotope label in chemical and biological research, disease diagnosis, drug manufacturing, etc.; it can be used in thermonuclear fusion reactions; it can be used as a light source; it can be used in optical fiber manufacturing; it can be used Military field, etc. Isotope labels are one of the important application fields of deuterium, and there is a strong demand for the development and production of deuterium-labeled compounds.

Deuterium-labeled compounds use the traceability of isotope atoms to label other molecules to study the movement and change patterns of substances. For example, the isotope atoms of the deuterium-labeled compound replace the hydrogen in the alkane derivative, so that the alkane derivative has an isotope effect, but its chemical properties will not change and it can continue to participate in chemical reactions. The isotope atoms have high stability and can be used to treat them. By tracking, the reaction process can be analyzed and measured. Deuterium-labeled compounds play an important role in the field of synthetic chemistry. Taking advantage of this feature, deuterium-labeled compounds can also be used in disease diagnosis and treatment.

According to the “In-depth Market Research and Investment Strategy Suggestions Report on Deuterium Labeled Compound Industry 2021-2025” released by the Industrial Research Center, the Drugs labeled with deuterium-labeled compounds (deuterated drugs) enter the human body and move with the body’s metabolism. By tracking deuterium-labeled compounds, we can understand the metabolic process of the human body, and use this to determine whether there is a disease in the human body, or use it to determine whether there is a disease in the human body. Drug efficacy. Deuterium-labeled compounds have important uses in disease diagnosis, disease treatment, life science research and other fields. In addition, deuterated drugs have better stability and significantly slow down their metabolism in the human body. Using this characteristic, new drugs with long half-lives, few side effects, and low metabolic burden can be developed.

The preparation methods of deuterium-labeled compounds mainly include chemical synthesis and hydrogen-deuterium exchange methods. The chemical synthesis method uses deuterium-containing reagents as raw materials and adopts different chemical reaction methods for preparation. For example, deuterated methyl iodide is used as the raw material and an alkylation reaction is used to generate deuterium-labeled compounds; the hydrogen-deuterium exchange method usually uses alkali, iron, transition Metals, rare metals, etc. are used as catalysts to exchange active hydrogen in the compound with active deuterium in the deuterated solvent molecules to generate deuterium-labeled compounds. There are many methods for preparing deuterium-labeled compounds, and more advanced preparation processes are still under continuous research.

Industry analysts said that globally, the main manufacturers of deuterium-labeled compounds include Zeochem of Switzerland, Cambridge CIL of the United States, and Tenova Pharmaceuticals of the United States. Inc, American Matreya LLC, American Polysciences, American SPEX CertiPrep, American MRC, etc. Globally, the United States has advanced science and technology and is in a leading position in the field of life science research. The research and development of deuterium-labeled compounds started early. Therefore, the world’s most well-known deuterium-labeled compound manufacturers are mainly concentrated in the United States. Compared with the United States, the number of deuterium-labeled compound manufacturers in my country is small, the annual output is limited, and demand is highly dependent on external sources.