Application and preparation of 4-hexyloxyphenol_Kain Industrial Additive

Background and overview^[1]

4-Hexyloxyphenol is a hydroquinone monoether compound. It is an important organic synthesis intermediate and is mainly used as a polymerization inhibitor for acrylonitrile, acrylic acid, methacrylic acid, ethylene acid and other monomers. Antioxidants in edible oils and cosmetics, stabilizers for photosensitive materials, and also used as antioxidants, plasticizers, and intermediates for drug synthesis.

Structure

Apply ^[2]

4-Hexyloxyphenol can be used as an intermediate in organic synthesis. For example, to prepare 4-hexyloxyphenol-3′, 5′-dinitrobenzoate, the specific steps are: add 5 parts of the primary product of 4-hexyloxyphenol and 0.6 parts of triethylamine with a stirrer In the three-necked flask, add 10 parts of tetrahydrofuran and stir to dissolve it completely, then add 5 parts of 3,5-dinitrobenzoyl chloride into the three-necked flask, and react at about 25℃ for about 3 Stop the reaction after an hour, pour the solution into 3 times the cold water for precipitation, filter after sufficient precipitation, and wash and dry the solid to obtain the intermediate product 4-hexyloxyphenol-3 for the preparation of monomer specific structure diamines. ‘,5’-dinitrobenzoate.

Preparation^[2]

Preparation of 4-hexyloxyphenol: Add 3 parts of 4,4′-dihydroxybenzene and 5 parts of potassium hydroxide into a three-necked flask with a stirrer, add 30 parts of methanol at a temperature of70 Stir at about 15°C to completely dissolve it, then add 3 parts of n-hexane bromide into the reactor, stir and react for about 24 hours, stop the reaction, cool to about 15°C, filter, and remove the filtrate Pour into distilled water about 4 times of the filtrate for precipitation. After sufficient precipitation, perform suction filtration. The white solid obtained is first washed with dilute hydrochloric acid with a weight concentration of 8%, then washed repeatedly with distilled water 3 times, dried for 24 hours, and recrystallized with ethanol. , the obtained product is the primary product 4-hexyloxyphenol for preparing monomer specific structure diamine.