Structural formula
Business number | 013B |
---|---|
Molecular formula | C21H30O5 |
Molecular weight | 362.46 |
label |
Yes, Cordazole, cortisol, hydrocortisone, 17-Hydroxycorticosterone, cortisol, Hydrocortin, Hydrocorticosterone, 11β,17α,21-trihydroxypregnant-4-en-3,20-dione, Hydrogenated adrenocorticoid hormone, Hydroprednisolone, 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M |
Numbering system
CAS number:50-23-7
MDL number:MFCD00011654
EINECS number:200-020-1
RTECS number:GM8925000
BRN number:1354819
PubChem number:24278466
Physical property data
1. Properties: White or off-white crystalline powder, odorless and bitter in taste. Deterioration when exposed to light
2. Density (g/mL, 25/4℃): Undetermined
3. Relative vapor density (g/mL, air=1): Undetermined
4. Melting point (ºC): 214-220℃ (decomposition);
5. Boiling point (ºC, normal pressure): Undetermined
6. Boiling point (ºC, 5.2 kPa): Not determined
7. Refractive index: Not determined
8. Flash point (ºC): 220
9. Ratio Optical rotation (º): [α]25D+157.5° (dioxane), +176° (chloroform), +162°-+169° (ethanol );
10. Autoignition point or ignition temperature (ºC): Undetermined
11. Vapor pressure (kPa, 25 ºC): Undetermined
12. Saturated vapor pressure (kPa, 60 ºC): Undetermined
13. Heat of combustion (KJ/mol): Undetermined
14. Critical temperature (ºC): Undetermined
15. Critical pressure (KPa): Undetermined
16. Log value of oil-water (octanol/water) partition coefficient: Undetermined
17. Explosion upper limit (%, V/V): Undetermined
18. Explosion lower limit� (%, V/V): Undetermined
19. Solubility: Insoluble in water (H2O: 100 mg/mL), hardly soluble in ether, slightly Soluble in chloroform, soluble in acetone and ethanol. Soluble in concentrated sulfuric acid and showing green fluorescence
Toxicological data
None
Ecological data
None
Molecular structure data
1. Molar refractive index: 95.57
2. Molar volume (cm3/mol): 281.3
3. Isotonic specific volume (90.2K ): 779.2
4. Surface tension (dyne/cm): 58.8
5. Polarizability (10-24cm3): 37.88
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 3
3. Number of hydrogen bond acceptors: 5
4. Number of rotatable chemical bonds: 2
5. Number of tautomers: 15
6. Topological molecule polar surface area 94.8
7. Number of heavy atoms: 26
8. Surface charge: 0
9. Complexity: 684
10. Number of isotope atoms: 0
11. Determine the number of atomic stereocenters: 7
12. Uncertain number of atomic stereocenters: 0
13. Determine the number of chemical bond stereocenters: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
This product should be sealed and stored in a dry place away from light.
Synthesis method
It can be separated from the adrenal gland fluid, or it can be made from 17α-hydroxyflavone as raw material through a series of reactions.
Purpose
Mainly used to rescue critical toxic infections; treat meningitis, pleurisy, arthritis, tenosynovitis, sprains, muscle strains, etc. It can also be used for rheumatoid arthritis, rheumatic fever, bronchial asthma, gout, atopic dermatitis, and itching. In addition, it can also be used for keratitis, scleritis, conjunctivitis, iridocyclitis, etc.