Haloperidol Haloperidol

Haloperidol structural formula

Structural formula

Business number 015P
Molecular formula C21H23ClFNO2
Molecular weight 375.86
label

haloperidol,

halopyridol,

1-(4-Fluorophenyl)-4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-butanone,

iohexol,

haloperidol,

4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone,

4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone,

4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobut

Numbering system

CAS number:52-86-8

MDL number:MFCD00051423

EINECS number:200-155-6

RTECS number:EU1575000

BRN number:None

PubChem number:24277917

Physical property data

1. Characteristics: White or off-white crystalline powder. Odorless and tasteless.


2. Density ( g/mL,25/4℃): Undetermined SPAN>


3. Relative steam Density (g/mL,AIR=1): Undetermined


4. Melting point ( ºC):148-149.4


5. Boiling point ( ºC,Normal pressure): Undetermined


6. Boiling point ( ºC, 13.33kpa):


7. Refractive Index : Undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical activity Degree (º,): Undetermined


10. Spontaneous ignition point or ignition temperature (ºC): Undetermined


11. Vapor Pressure (kPa,25ºC): Undetermined


Isotonic specific volume(90.2K)797.8


4. Surface Tension(dyne/cm)47.9


5. Polarizability(10-24cm3)40.04

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 6

5. Number of tautomers: 2

6. Topological molecule polar surface area 40.5

7. Number of heavy atoms: 26

8. Surface charge: 0

9. Complexity: 451

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

Should be sealed and stored away from light.

Synthesis method

By4-p-chlorobenzene-4-hydroxyl piper andγChloro-p-fluorophenbutanone condensation And get. IntermediateγChlorofluorobenzene is composed of fluorobenzene,γbutyrolactone and sulfoxide chloride as raw materials.

Purpose

Antipsychotic drugs, formerly known as strong tranquilizers, are mainly used to control schizophrenia and other patients with hallucinations, delusions, Excitement, impulsiveness and other related diseases. Haloperidol is mainly used to combat mania and hallucinations in acute and chronic schizophrenia. It is effective in controlling excitement and agitation, but it is ineffective in treating depression and apathy in schizophrenia.

LY: Times New Roman; LETTER-SPACING: 0.4pt; mso-hansi-font-family: 宋体”>-Made from butyrolactone and sulfoxide chloride as raw materials.

Purpose

Antipsychotic drugs, formerly known as strong tranquilizers, are mainly used to control schizophrenia and other patients with hallucinations, delusions, Excitement, impulsiveness and other related diseases. Haloperidol is mainly used to combat mania and hallucinations in acute and chronic schizophrenia. It is effective in controlling excitement and agitation, but it is ineffective in treating depression and apathy in schizophrenia.

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.chemicalchem.com/archives/21394

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