Toluene diisocyanate manufacturer Knowledge Methyl iodide Iodomethane

Methyl iodide Iodomethane

Structural formula of methyl iodide

Structural formula

Business number 01HL
Molecular formula CH3I
Molecular weight 141.94
label

Methyl iodide,

Monoiodomethane,

Methyl iodide,

methylation reagents,

Extinguishing agent,

Halogenated hydrocarbon solvents

Numbering system

CAS number:74-88-4

MDL number:MFCD00001073

EINECS number:200-819-5

RTECS number:PA9450000

BRN number:969135

PubChem number:24857202

Physical property data

1. Properties: Colorless and transparent liquid with a special odor. Turns brown when exposed to light. [12]

2. Melting point (℃): -66.5[13]

3. Boiling point (℃): 42.5[14]

4. Relative density (water = 1): 2.3[15]

5. Relative vapor Density (air=1): 4.89[16]

6. Saturated vapor pressure (kPa): 50 (20℃)[17]

7. Heat of combustion (kJ/mol): -813.8[18]

8. Critical temperature (℃): 254.8[19]

9. Critical pressure (MPa): 7.36[20]

10. Octanol/water partition coefficient: 1.51~1.69[21]

11. Solubility: slightly soluble in water, soluble in ethanol and ether. [22]

12. Refractive index at room temperature (n25): 1.5270

13. Eccentricity factor: 0.193

14. Solubility parameter (J·cm-3)0.5: 20.172

15. van der Waals area (cm2·mol-1): 4.600×109

16. van der Waals volume (cm3 ·mol-1): 32.850

17. Gas phase standard claims heat (enthalpy) (kJ·mol-1): 14.7

18. Gas phase standard entropy (J·mol-1·K-1): 253.81

19. Gas phase standard Free energy of formation (kJ·mol-1): 16.4

20. Gas phase standard hot melt (J·mol-1·K -1): 44.08

21. Liquid phase standard claims heat (enthalpy) (kJ·mol-1): -12.3

22. Liquid phase standard entropy (J·mol-1·K-1): 162.8

23. Liquid phase standard free energy of formation (kJ ·mol-1): 16.5

24. Liquid phase standard hot melt (J·mol-1·K-1):82.91

Toxicological data

1. Acute toxicity[23]

LD50: 100~200mg/kg (rat oral)

LC50: 1300mg/m3 (rat inhalation, 4h)

2. Irritation[24] Human Transdermal: 1g (30min), mild irritation.

3. Mutagenicity [25] Microbial mutagenicity: Salmonella typhimurium 2μl/dish; Escherichia coli 20μmol/L. Mammalian somatic cell mutagenicity: mouse lymphocytes 15mg/L (2h). DNA damage: E. coli 1μmol/L.

4. Carcinogenicity [26] IARC Carcinogenicity Comment: G3, insufficient evidence of carcinogenicity to humans and animals.

Ecological data

<ester. Phenolic hydroxyl groups can often also be methylated under such conditions[3], while fatty alcohol methylation usually occurs in aprotic polar solvents using stronger bases (Formula 2) [4].

S -Methylation Methyl iodide can methylate sulfides such as thiols [5] to obtain sulfides and sulfonium salts. For example, the reaction between thioamide and methyl iodide in THF can methylate thio to form thioether (formula 3)[6].

N -Methylation Methylation of ammonia and primary amines with methyl iodide is generally not a good method because further methylation will occur, but for secondary and tertiary amines Methylation is a better method and can be used to prepare tertiary amines and quaternary ammonium salts[7]. In acetonitrile solvent, tritylamine is methylated with methyl iodide to obtain the product with higher yield (Formula 4)[8]. The nitrogen atoms in the heterocyclic ring can also be methylated with methyl iodide (Formula 5)[9,10].

P -Methylation The reaction between three-coordinated phosphorus and methyl iodide can generate  salt (formula 6) [11]. Usually, this reaction occurs in polar solvents such as acetonitrile, Perform in DMF or THF.

3. Used in medicine, organic Synthesis, testing of pyridine, microscopy, etc. [35]

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.chemicalchem.com/archives/21907

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