Physostigmine Physostigmine

Structural formula

• Numbering system
• Physical property data
• Toxicological data
• Ecological data
• Molecular structure data
• Computing chemical data
• More
  • Properties and Stability
  • Storage method
  • Synthesis method
  • Purpose

Numbering system

CAS number:57-47-6

MDL number:MFCD00151090

EINECS number:200-332-8

RTECS number:TJ2100000

BRN number:91230

PubChem number:24277867

Physical property data

1. Character: Colorless rhombic prism or flake crystal.

2. Density (g/mL,25/4℃): Undetermined

3. Relative vapor density (g/mL,AIR=1): Undetermined

4. Melting point (ºC):105~106℃ (there are also unstable low melting point products, as 86～87℃)

5. Boiling Point (ºC,Normal pressure): Undetermined

6. Boiling Point (ºC,5.2kPa): Undetermined

7. Refractive Index: Undetermined

8. Flashpoint (ºC): Undetermined

9. Specific rotation (º):[α ]D17 －76°（C＝1.3, in chloroform), [α]D25 －120°（C＝1, in benzene )

10. Autoignition point or ignition temperature (ºC): Undetermined

11. Vapor pressure (kPa,25ºC): Undetermined):602.3

4. Surface Tension (dyne/cm):42.3

5. Polarizability(10^-24cm³): 30.59

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 1

3. Number of hydrogen bond acceptors: 4

4. Number of rotatable chemical bonds: 2

5. Number of tautomers: 2

6. Topological molecule polar surface area 44.8

7. Number of heavy atoms: 20

8. Surface charge: 0

9. Complexity: 403

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 2

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None

Storage method

This product should be sealed and stored in a cool, dark place.

Synthesis method

Physostigmine can be extracted from physostigmine seeds and treated with salicylic acid. It can also be synthesized artificially.

Purpose

Biochemical research. It can inhibit cholinesterase, excite smooth muscle and striated muscle, narrow pupils, reduce intraocular pressure, and is mainly used for glaucoma, etc. The effect is stronger and longer-lasting than pilocarpine.

ast-language: ZH-CN; mso-bidi-language: AR-SA”> Can inhibit cholinesterase and excite smooth muscle and striated muscle. It can narrow pupils and reduce intraocular pressure, and is mainly used for glaucoma. The effect is stronger and longer-lasting than pilocarpine.