Toluene diisocyanate manufacturer Knowledge Hydrochlorothiazide Hydrochlorothiazide

Hydrochlorothiazide Hydrochlorothiazide

Hydrochlorothiazide structural formula

Structural formula

Business number 019Y
Molecular formula C7H8ClN3O4S2
Molecular weight 297.74
label

6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide,

6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Numbering system

CAS number:58-93-5

MDL number:MFCD00051765

EINECS number:200-403-3

RTECS number:DK9100000

BRN number:625101

PubChem number:24277806

Physical property data

1. Characteristics: White needle crystal. Has a strong special smell.


2. Density (g/mL,25/4):1.839


3. Relative vapor density (g/mL,Air=1): Undetermined


4. Melting point (ºC):69~70


5. Boiling point (ºC,Normal pressure): Undetermined


6. Boiling point (ºC, 3.07kPa): 164


7. Refractive index: Undetermined


8. Flash Point (ºC): Undetermined


9. Specific optical rotation (º): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (kPa,25ºC): Undetermined


12. 3. isotonic ratio (90.2K):493.3


4. Surface Tension (dyne/cm):62.8


5. Polarizability(10-24cm3): 24.86

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 7

4. Number of rotatable chemical bonds: 1

5. Number of tautomers: none

6. Topological molecule polar surface area 135

7. Number of heavy atoms: 17

8. Surface charge: 0

9. Complexity: 494

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

None yet

Storage method

This product should be sealed and stored away from light.

Synthesis method

Obtained from chlorosulfonation of m-chloroaniline5-Chlorine -2, 4- Chlorosulfonylanilide, generated by ammonia reaction5-Chlorine-2, 4-Sulfaniline is finally obtained by combining it with formaldehyde.

Purpose

This product is a typical representative of thiazide medium-acting diuretics and is widely used in the United States1985Ranked first in annual drug sales. Because it is easy to take, has a moderate effect, and is suitable for all kinds of edema, it is the most common adverse reaction caused by potassium excretion in clinical practice, and potassium salt needs to be supplemented during use. Mouse Jinyong injectionLD50for590mg/kg , taken orallyLD50 is greater than 8000mg/kg.

so-hansi-font-family: Arial”>,4-Chlorosulfonyl anilide, produced by ammonia reaction5-Chlorine-2,4 –Sulfaniline is finally obtained by combining formaldehyde.

Purpose

This product is a typical representative of thiazide medium-acting diuretics and is widely used in the United States1985Ranked first in annual drug sales. Because it is easy to take, has a moderate effect, and is suitable for all kinds of edema, it is the most common adverse reaction caused by potassium excretion in clinical practice, and potassium salt needs to be supplemented during use. Mouse Jinyong injectionLD50for590mg/kg , taken orallyLD50 is greater than 8000mg/kg.

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.chemicalchem.com/archives/22733

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