Toluene diisocyanate manufacturer Knowledge Ethyl Formate Ethyl Formate

Ethyl Formate Ethyl Formate

Ethyl formate structural formula

Structural formula

Business number 0306
Molecular formula C3H6O2
Molecular weight 74.08
label

Ethyl formate,

Ethyl formate,

Formic acid ethyl ester,

Formic ether,

Ethyl methanoate,

fungicides,

larvicides,

fumigant,

food additives,

Flavor enhancer

Numbering system

CAS number:109-94-4

MDL number:MFCD00003294

EINECS number:203-721-0

RTECS number:LQ8400000

BRN number:906769

PubChem number:24889112

Physical property data

1. Properties: colorless, easy-flowing liquid with aromatic odor. [1]

2. Melting point (℃): -80[2]

3. Boiling point (℃): 54.3[3]

4. Relative density (water = 1): 0.92[4]

5. Relative vapor Density (air=1): 2.55[5]

6. Saturated vapor pressure (kPa): 25.6 (20℃)[6]

7. Heat of combustion (kJ/mol): -1630[7]

8. Critical temperature (℃): 235.3[8]

9. Critical pressure (MPa): 4.74[9]

10. Octanol/water partition coefficient: 0.23 [10]

11. Flash point (℃): -20 (CC) [11]

12. Ignition temperature ( ℃): 455[12]

13. Explosion upper limit (%): 16.5[13]

14. Explosion Lower limit (%): 2.7[14]

15. Solubility: Slightly soluble in water, soluble in most organic solvents such as benzene, ethanol, and ether. [15]

16. Viscosity (mPa·s, 15ºC): 0.419

17. Heat of evaporation (KJ/mol, 54.15ºC): 30.15

18. Heat of formation (KJ/mol): 369.28

19. Specific heat capacity (KJ/(kg·K), 15~30ºC, constant pressure): 2.00

20. Boiling point rising constant: 2.086

21. Conductivity (S/m, 20ºC): 1.45×10-9

22. Thermal conductivity (W/(m·K), 12ºC): 0.1583

23. Volume expansion coefficient (K-1, 20ºC): 0.00141

24. Critical density (g·cm-3): 0.323

25. Critical volume (cm3·mol-1): 229

26. Critical compression factor: 0.257

27. Eccentricity factor: 0.285

28. Lennard-Jones parameters (A): 11.14

29. Lennard-Jones parameter (K): 161.3

30. Solubility parameter (J·cm-3)0.5: 18.939

31. van der Waals area (cm2·mol-1): 6.440×109 sup>

32. van der Waals volume (cm3·mol-1): 42.740

33. Gas phase standard Heat of combustion (enthalpy) (kJ·mol-1): -1639.7

34. Gas phase standard claims heat (enthalpy) (kJ·mol-1): -398.3

35. Liquid phase standard combustion heat (enthalpy) (kJ·mol-1): -1607.5

36. Liquid phase Standard claims heat (enthalpy) (kJ·mol<After esterification by heating under ambient conditions, it is obtained by dehydration and distillation with phosphorus pentoxide or anhydrous calcium chloride.

Refining method: Since ethyl formate is easily hydrolyzed, it often contains free formic acid and ethanol and is acidic. During refining, it is first washed with sodium carbonate solution, then dried and fractionated with anhydrous potassium carbonate or phosphorus pentoxide. Calcium chloride forms a crystalline complex with ethyl formate and is not suitable for use as a desiccant.

4. Preparation method:

In a reaction bottle equipped with a reflux condenser, add 61g of 98% formic acid (1.33mol) and 31g of absolute ethanol (2) (0.67 mol), one particle of zeolite, heated to reflux for 24 hours. Change to a distillation device for distillation, collect fractions below 62°C, saturate the leachate with sodium chloride, and then wash with saturated sodium bicarbonate and saturated sodium chloride solutions in sequence. Dry with anhydrous sodium sulfate, fractionate, and collect the fraction at 53-54°C to obtain 36 g of butyl formate (1), with a yield of 72%. [25]

Purpose

1. Ethyl formate is used as a solvent for nitrocellulose, cellulose acetate, etc., as well as a fungicide, larvicidal and fumigant for food, cigarettes, cereals, dried fruits, etc. As a flavor, ethyl formate can be used to blend the aromas of peaches, bananas, apples, apricots, pineapples, berries, etc. It can also be used as a spice for butter, brandy, liqueur, whiskey, etc. Ethyl formate is also an intermediate in organic synthesis. For example, in the pharmaceutical industry, it is used in the production of anti-tumor drugs Fulcedine and vitamin B1; ethyl formate and acetone are condensed in sodium methoxide-xylene solution to obtain sodium acetyl vinyl alcohol, which is condensed with acetyl glycine ester and then reacted with thiocyanate Cyclization with potassium can give 2-mercaptoimidazole-4-carboxylic acid ethyl ester. Ethyl formate is used to produce drugs such as Houttuynia cordata, Tongjingning, Anadrol, pyrantel, pyridine, Lixuesheng, and fully synthetic anisodamine.

2. Used as a solvent for cellulose acetate and cellulose nitrate, as well as for flavor synthesis and pharmaceutical production. [24]

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