[Alias]Monochloroacetic acid, monochloroacetic acid, chloroacetic acid.
[Molecular Formula]C2H3CO2
[Structural Formula]C1CH2COOH
[Properties]Chloroacetic acid is a halogenated acid. An H atom on the methyl group in the acetic acid molecule is replaced by a Cl atom. The final product is colorless or light yellow crystals with a pungent odor. Boiling point 187.85℃, relative density I.4043 (40℃), refractive index 1.4330 (60℃). It has four crystal forms (α, β, γ, and δ types), with melting points of 63°C (α type), 56.2°C (β type), 52.5°C (γ type), and 42.75°C (δ type) respectively. The melting point of industrial products is 61-63℃. Easily soluble in water, benzene, ethanol and ether. It is a more active acid than acetic acid and has stronger acidity than acetic acid. It can turn blue litmus paper red. The cl atoms in chloroacetic acid can be replaced by groups such as -OH, -SH, -CN, -NH2, -F etc. replaced. It is highly corrosive and can destroy metal, rubber and cork.
[Use]It is an intermediate for dyes, medicines, pesticides, synthetic resins and other organic synthetic materials. Used in the dye industry to produce indigo dye. In the pharmaceutical industry, it is used to synthesize barbiturates, caffeine, epinephrine, vitamin R6 and glycine, etc. The pesticide industry is used to produce dimethoate, 2,4-D butyl ester (herbicide;, 2,4,5-T (herbicide and growth stimulant), thiocyanacetic acid and naphthaleneacetic acid, etc. Chloroacetic acid is also a An important carboxymethylating agent, used to prepare sodium carboxymethylcellulose, ethylenediaminetetraacetic acid, etc., and also used as a non-ferrous metal flotation agent and chromatographic analysis reagent.
[Brief preparation method] Glacial acetic acid is prepared by reacting with chlorine at about 95°C under the action of sulfur (or red phosphorus) catalyst Obtain chloroacetic acid.
[Safety and Protection]Chloroacetic acid is a secondary organic acid corrosive substance, hazardous regulation number: 94003. Packed in woven bags lined with plastic bags or plastic lined iron barrels, with a net weight of 25kg or 50kg per bag (or barrel), and marked with the “corrosive product” mark. Should be stored in a cool, dry place.
Chloroacetic acid is highly toxic, highly corrosive and irritating. If it touches the skin, rinse it with plenty of water. Severe cases should be sent to the hospital for treatment.