Toluene diisocyanate manufacturer Knowledge Neostigmine Neoserine Bromide

Neostigmine Neoserine Bromide

Neostigmine bromide structural formula

Structural formula

Business number 037E
Molecular formula C12H19BrN2O2
Molecular weight 303.20
label

Prussian Ming,

neostigmine bromide,

(3-Dimethylcarbamoyloxyphenyl)trimethylammonium bromide,

3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide,

aromatic compounds

Numbering system

CAS number:114-80-7

MDL number:MFCD00011795

EINECS number:204-054-8

RTECS number:BR3150000

BRN number:None

PubChem number:24277854

Physical property data

1. Characteristics: White crystalline powder. Odorless and non-bitter.


2. Density (g/mL, 25): Undetermined


3. Relative vapor density (g/mL,air =1): Undetermined


4. Melting point (ºC):167(decomposed)


5. Boiling point (ºC,normal pressure): Undetermined


6. Boiling point (ºC,KPa)Undetermined


7. Refractive index n20/D):Undetermined


8. Flashpoint (ºC): Undetermined


9. Specific optical rotation (ºC): Undetermined


10. Autoignition point or ignition temperature (ºC): Undetermined


11. Vapor pressure (mmHg,38ºC): Undetermined


12. Saturated vapor pressure (kPa, ºC): Undetermined


13. Heat of combustion (KJ/mol): Undetermined


14. Critical temperature (ºC): Undetermined


15. Critical pressure (KPa): Undetermined


16. Oil-water (octanol/water) partition coefficient Log value of : Undetermined


17. Explosion limit (%,V/V): Undetermined


18. Lower explosion limit (%,V/V): Undetermined


19. Solubility:Easily soluble in water (1gThis product is soluble in 1mlwater), ethanol, and chloroform , almost insoluble in ether.

Toxicological data

1. Acute toxicity: Rat oral LD5O: 51mg/kg


Rat transperitonealLDLO835ug/kg


Rat subcutaneously LD5O370ug/kg


Rat intravenous LD5O: 165ug/kg


Orally administered to miceLD5O7mg/kg


Mouse transperitonealLD5O610ug/kg


Mouse subcutaneouslyLD5O130ug/kg


Cat via mouth LD5O7449ug/kg


Cat Meridian VeinLD5O171ug/kg

Ecological data

None yet

Molecular structure data

None yet

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 0

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 3

5. Number of tautomers: none

6. Topological molecule polar surface area 29.5

7. Number of heavy atoms: 17

8. Surface charge: 0

9. Complexity: 246

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 2

Properties and stability

None yet

Storage method

None yet

Synthesis method

Meta-dimethylaminophenol (see 15070) and dimethylcarbamoyl chloride via ester The neostigmine base is obtained by chemical reaction, and then the quaternary ammonium salt is reacted with methyl bromide to obtain neostigmine bromide. For example, by reacting the neostigmine base with dimethyl sulfate to form a quaternary ammonium salt, neostigmine methyl sulfate ([51-60-5]).

Purpose

This product has a reversible cholinesterase inhibitory effect, causing acetylcholine to not be enzymatically decomposed and existing in cholinergic nerve endings for a long time, which can cause Exciting smoothing machine and skeletal muscle; strong effect on skeletal muscles, small miotic force; mostly used for myasthenia gravis, postoperative abdominal distension and urinary retention, and can also be used for supraventricular paroxysmal tachycardia, and Detoxification of tubocurarine overdose. Neostigmine methyl sulfate is for injection.

N>Rat intravenous LD5O165ug/kg


Orally administered to miceLD5O7mg/kg


Mouse transperitonealLD5O610ug/kg


Mouse subcutaneouslyLD5O130ug/kg


Cat via mouth LD5O7449ug/kg


Cat Meridian VeinLD5O171ug/kg

Ecological data

None yet

Molecular structure data

None yet

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 0

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 3

5. Number of tautomers: none

6. Topological molecule polar surface area 29.5

7. Number of heavy atoms: 17

8. Surface charge: 0

9. Complexity: 246

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 2

Properties and stability

None yet

Storage method

None yet

Synthesis method

Meta-dimethylaminophenol (see 15070) and dimethylcarbamoyl chloride via ester The neostigmine base is obtained by chemical reaction, and then the quaternary ammonium salt is reacted with methyl bromide to obtain neostigmine bromide. For example, by reacting the neostigmine base with dimethyl sulfate to form a quaternary ammonium salt, neostigmine methyl sulfate ([51-60-5]).

Purpose

This product has a reversible cholinesterase inhibitory effect, causing acetylcholine to not be enzymatically decomposed and existing in cholinergic nerve endings for a long time, which can cause Exciting smoothing machine and skeletal muscle; strong effect on skeletal muscles, small miotic force; mostly used for myasthenia gravis, postoperative abdominal distension and urinary retention, and can also be used for supraventricular paroxysmal tachycardia, and Detoxification of tubocurarine overdose. Neostigmine methyl sulfate is for injection.

This article is from the Internet, does not represent the position of Toluene diisocyanate reproduced please specify the source.https://www.chemicalchem.com/archives/27036

author:

Previous article
Next article
Contact Us

Contact us

+86 - 152 2121 6908

Online consultation: QQ交谈

E-mail: sales@newtopchem.com

Working hours: Monday to Friday, 9:00-17:30, closed on holidays
Follow wechat
Scan wechat and follow us

Scan wechat and follow us

Follow Weibo
Back to top
Home
E-mail
Products
Search