Cyclohexene (tetrahydrobenzene) industry standards continue to improve, and my country’s R&D enthusiasm continues to rise

Cyclohexene, also known as tetrahydrobenzene, has a chemical formula of C6H10 and is an organic compound. Cyclohexene appears as a colorless and transparent liquid with a pungent odor. It is miscible with ether, petroleum ether, ethanol, carbon tetrachloride and acetone, and is insoluble in water. Cyclohexene is volatile, flammable, and can undergo addition reactions. It is widely used in many fields such as medicine, synthetic rubber, and organic synthesis.

In order to regulate the development of the cyclohexene industry, the Chinese government and relevant industry associations have launched a number of industry standards and group standards. In April 2023, the Ministry of Industry and Information Technology approved the release of the industry standard “HG/T 4002-2023 Cyclohexene for Industrial Use”. The standard will be officially implemented from November 1, 2023. Its drafting unit is Henan Shenma Nylon Chemical Co., Ltd. Company, Chongqing Huafeng Chemical Co., Ltd., Shandong Hualu Hengsheng Chemical Co., Ltd., etc.

According to the “2023-2028 China cyclohexene (tetrahydrobenzene) industry market in-depth research and development prospect forecast report span>》shows that cyclohexene is widely used in many fields such as medicine, synthetic rubber, and organic synthesis. In the field of medicine, cyclohexene can be used as a pharmaceutical intermediate to produce active drugs; in the field of synthetic rubber, cyclohexene can be used as a rubber additive; in the field of organic synthesis, cyclohexene can be used to prepare hexahydrobenzoic acid, hexane Diacid, acetaldehyde and maleic acid, etc. The production process of adipic acid is mainly based on cyclohexane method and cyclohexene method. The cyclohexene method uses cyclohexene and benzene as the main raw materials, and obtains the finished product through hydration reaction and nitric acid oxidation reaction. This method has high yield, Good quality of finished products and other advantages.

In recent years, cyclohexene has been widely used in the pharmaceutical field, driving enthusiasm for its research and development to continue to rise. In November 2022, Lei Xiaoguang’s research group at the School of Chemistry and Molecular Engineering at Peking University used chemical enzymatic methods to combine the metal-catalyzed decarboxylation functionalization reaction with the D-A reaction to achieve the structural diversity of the cyclohexene skeleton. This research has been favored by Funded by the Swiss pharmaceutical company Novartis, it will be widely used in the efficient synthesis of multi-substituted chiral cyclohexane skeletons in the future.

In terms of market competition, my country’s major cyclohexene manufacturers include Shenma, Luxi Chemical, Baling Petrochemical, etc. The main business of Shenma Co., Ltd. is chemical and chemical fiber products. Its subsidiary Pingdingshan Shenma Engineering Plastics Co., Ltd. has an annual cyclohexene production capacity of 32,800 tons. According to the annual report of Shenma Co., Ltd., the company will achieve revenue of 13.56 billion yuan in 2022.

Industry analysts said that as an organic synthesis intermediate, cyclohexene has strong market demand and good industry development prospects in the future. As research continues to deepen, its application scope will expand. In recent years, thanks to the continuous improvement of industry standards and technological progress, my country’s high-quality cyclohexene market share has continued to increase. It is expected that in the future, as local enterprises continue to exert their efforts, my country’s cyclohexene production and quality will further increase.