Background and overview[1][2]
Benzene is an aromatic hydrocarbon. Benzene is insoluble in water, but soluble in organic solvents such as ethanol and ether. Benzene-D6 (C6D6), a deuterated derivative of benzene, is a standard purity solvent used for NMR (nuclear magnetic resonance) analysis and its Soret coefficient S (T) was measured by transient holographic grating technology. The first resonance Raman spectrum and infrared absorption intensity (in the range of 5000-450cm-1) of benzene-D6 have been reported, and benzene-D6 is involved in the synthesis of isotope-labeled samples.
Apply[2-3]
Benzene-D6 is a type of organic material with special functions and has important applications in biomedical imaging and genetic testing. Examples of its application are as follows:
1) Preparation of 1,2,3,4-tetradeuterated-9-bromoanthracene. This method uses benzene-D6 and phthalic anhydride as raw materials, undergoes multi-step reactions such as condensation, ring closure, reduction and bromination, and then purifies to obtain the product 1,2,3,4-tetradeuterated-9 – Bromanthracene. Since the raw materials used in the synthesis method of 1,2,3,4-tetradeuterated-9-bromoanthracene provided by the present invention are low in price, the solvent usage is small and easy to recover, it can ensure product purity and yield on the premise of ensuring product purity and yield. Significantly reduces production costs, making it suitable for industrial production. In addition, this synthesis method also has the advantages of simple operation, convenience, and safety.
2) For the determination of volatile organic compounds in the mainstream smoke of a cigarette, the method includes the following steps: (1) Filling the smoking machine with an adsorption tube with an adsorbent material for capturing volatile organic compounds In the adsorption tube of the capture device, capture the volatile organic compounds in the mainstream smoke of the cigarette; (2) transfer the adsorption material containing the volatile organic compounds captured in step (1) to a desorption container, and then Add the desorption solution for desorption, and add the benzene-D6 internal standard to obtain a desorption solution containing volatile organic compounds; (3) Use a gas chromatography-mass spectrometer to desorb the volatile organic compounds obtained in step (2). The solution is tested. The method of the invention has the advantages of simple operation, rapidity, high sensitivity and good repeatability.
Main reference materials
[1]–Chinese Metallurgical Encyclopedia·Coking Chemical Industry
[2] CN201010524837.81, synthesis method of 2,3,4-tetradeutero-9-bromoanthracene
[3] CN201410481687.5 A method for the determination of volatile organic compounds in mainstream cigarette smoke
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