Trifluoromethanesulfonic anhydride (Tf2O) is widely used and has broad application prospects in the pharmaceutical field.

​​ ​ Trifluoromethanesulfonic anhydride (Tf2O), also known as trifluoromethanesulfonic anhydride, has a chemical formula of C2F6O5S2 and is an important organic synthesis reagent. Trifluoromethanesulfonic anhydride appears as a colorless liquid with a pungent odor. It is soluble in water and insoluble in most carbonic acids, ketones and aromatic hydrocarbons. Trifluoromethanesulfonic anhydride has the characteristics of good hygroscopicity, strong corrosiveness, and easy volatility. It is widely used in fields such as electronic chemistry, medicine, pesticides, fuels, plastics, and sugar refining.

Trifluoromethanesulfonic acid is the main raw material of trifluoromethanesulfonic anhydride. Trifluoromethanesulfonic acid has the characteristics of thermal stability, reducing property, and strong acidity, and is widely used in many fields. In the early stages of industry development, my country’s triflate was highly dependent on imports due to factors such as high technical barriers. In recent years, with the continuous improvement of independent research and development capabilities of local enterprises, the localization process of my country’s triflate market has been accelerating, which has provided favorable conditions for the development of the triflate industry.

Trifluoromethanesulfonic anhydride is used in a wide range of applications, including electronic chemistry, medicine, pesticides, fuels, plastics, sugar refining, etc. In the field of electronic chemistry, triflic anhydride can be used to produce electronically conductive polymers; in the field of medicine, triflic anhydride can be used to produce anti-lung cancer drugs; in the field of pesticides, triflic anhydride can be used to synthesize herbicides; In the field of plastics, triflate can be used for plastic modification.

According to the “2023-2028 China Trifluoromethanesulfonic Anhydride (Tf2O) Industry Market In-depth Research and Development Prospects Forecast Report span>》shows that in recent years, trifluoromethanesulfonic anhydride has shown broad application prospects in the pharmaceutical field. Alectinib, also known as alectinib, is a new anti-lung cancer drug independently developed by Roche Pharmaceuticals. It can be used to treat locally advanced or metastatic non-small cell lung cancer (NSCLC) with positive ALK gene mutations. In recent years, the number of lung cancer patients worldwide has continued to grow, and the sales of alectinib, as a first-line anti-lung cancer drug, have continued to increase. Trifluoromethanesulfonic anhydride can be used as an intermediate for alectinib. With the rapid development of downstream industries, the market demand for trifluoromethanesulfonic anhydride is becoming increasingly strong.

The main manufacturers of trifluoromethanesulfonic anhydride in my country include Jiangxi Guohua Industrial Co., Ltd., CSSC (Handan) Perry Special Gas Co., Ltd., Wuhan Xiju Biotechnology Co., Ltd., etc. Compared with overseas developed countries, my country’s triflate industry started late and has a low market share. In the future, as the technological maturity of local companies increases, my country’s triflate production and quality will further increase.

Industry analysts said that trifluoromethanesulfonic anhydride has the characteristics of good hygroscopicity and strong corrosiveness, and has broad applications in the pharmaceutical field. prospect. In the future, as the development of downstream industries accelerates, the market demand for trifluoromethanesulfonic anhydride will further grow. At present, due to factors such as high technical barriers, my country’s triflate market penetration is low. In the future, driven by the technological innovation of local companies, the industry’s development space will be further expanded.