As a subdivided product of deuterated solvents, deuterated chloroform has broad application prospects.

Deuterated solvents include deuterated methanol, deuterated ethanol, deuterated chloroform, and deuterated dimethyl sulfoxide. Deuterated chloroform, also known as chloroform-d and chloroform-d1, is a deuterated product of chloroform, with the molecular formula CDCl3. Deuterated chloroform appears as a colorless liquid, tastes pungent and sweet and has a special aromatic odor. It is insoluble in water and soluble in organic solvents. Deuterated chloroform is volatile and is widely used in fields such as optoelectronic material modification, pharmaceutical synthesis, and nuclear magnetic resonance spectroscopy.

The preparation of deuterated chloroform usually uses calcium oxide and hexachloroacetone as the main raw materials. After stirring, deuterium and oxygen compounds are added, and finally the finished product is obtained through processes such as heating and distillation. my country is a major producer of calcium oxide, and its output has long been a global leader. Benefiting from the wide sources and sufficient supply of raw materials, the development speed of my country’s deuterated chloroform industry continues to accelerate. In recent years, local companies and related scientific research institutions have continued to increase research on deuterated chloroform preparation technology. It is expected that the market share of high-quality deuterated chloroform in my country will continue to expand in the future.

According to the “2023-2028 China Deuterated Chloroform Industry Market In-depth Research and Development Prospects Forecast Report released by the Industrial Research Center, The medical field is the largest demand side for deuterated chloroform. As my country’s medical level continues to improve, the development prospects of the deuterated chloroform industry continue to improve. Deuterated chloroform is cheap and has good solubility in organic solvents. As a reagent for NMR spectroscopy, it can improve the resolution of NMR spectra. In recent years, the popularity of nuclear magnetic resonance technology in our country has continued to increase, and the number of nuclear magnetic resonance equipment in our country will exceed 14,000 units in 2022. Against this background, the market size of deuterated chloroform continues to expand.

In recent years, the application research of deuterated chloroform has been deepened and many new developments have been made. In 2022, Professor Yang Hua’s research group at Central South University used deuterated chloroform as a trideuterated methyl source to achieve trideuterated methylation of quinoxalinone. This technology is expected to play an important role in the synthesis of deuterated drugs in the future.

Deuterated chloroform is a subdivided product of deuterated solvents, accounting for nearly 50% of its market share. Driven by market demand, many companies in my country have laid out the research and development and production tracks of deuterated chloroform. Nanjing Haolv Biotechnology Co., Ltd., Ningbo Cuiying Chemical Technology Co., Ltd., Shandong Faraday Deuterium Source Technology Co., Ltd., Shanghai Yaxing Biomedical Technology Co., Ltd., Shanghai Titan Technology Co., Ltd., etc. are the main suppliers of deuterated chloroform in my country.

          Industry analysts said that deuterated chloroform, as the most widely used deuterated solvent, has a rapid development momentum in the industry. In recent years, as the prosperity of the nuclear magnetic resonance and pharmaceutical synthesis industries continues to increase, the application scope of deuterated chloroform continues to expand. There are many suppliers of deuterated chloroform in my country, but they are mainly small and medium-sized enterprises, and the industry concentration is low. In the future, with in-depth research and technological advancement, the deuterated chloroform industry will gradually develop in the direction of high quality.