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Preparation and application of p-tert-butylbenzoic acid_Kain Industrial Additive
Background and overview[1] P-tert-butylbenzoic acid (PTBA) is colorless needle-shaped crystals or crystalline powder. It is a derivative of benzoic acid and an important organic synthesis intermediate…
Preparation of 2-chloro-4-methylphenylboronic acid_Kain Industrial Additive
Background and overview[1] 2-Chloro-4-methylbenzeneboronic acid can be used as a pharmaceutical synthesis intermediate and is often used as a raw material for coupling reactions such as Suzuki. 2-Chlo…
Preparation of Sitagliptin Impurity 13_Kain Industrial Additive
Background and overview[1] Sitagliptin, chemical name (2R)-4-oxo-4-[3-trifluoromethyl-5,6-dihydro[1,2,4]triazole[4 , 3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)-butan-2-amine, which is a dipeptide…
Preparation of 2-fluoro-4-iodoaniline_Kain Industrial Additive
Background and Overview[1] 2-Fluoro-4-iodoaniline is one of the most important intermediates in the dye industry. In the dye industry, it can be used to manufacture acid ink blue G, acid medium BS, ac…
Preparation of 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepine-2-one_Kain Industrial Additive
Background and Overview[1] 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepine-2-one is an intermediate in the synthesis of benazepril hydrochloride. Benazepril hydrochloride is a first-line antihypertensive …
Preparation of benzene sulfonyl chloride_Kain Industrial Additive
Background and Overview[1] Benzenesulfonyl chloride is a white flake crystal with a melting point of 69-71°C. It is an important organic synthesis drug intermediate and is mainly used in the synthesis…
Preparation of m-methoxypropiophenone_Kain Industrial Additive
Background and Overview[1] Me-methoxypropiophenone is a key intermediate used in the production of the drug tapentadol. Tapentadol is a novel oral analgesic drug that acts on the central nervous syste…
Application of (R)-2-(aminoethyl)-4-chlorophenol_Kain Industrial Additive
Background and overview[1][2] (R)-2-(Aminoethyl)-4-chlorophenol is a chiral organic intermediate, which can be prepared by reductive amination of 2-hydroxy-5-chloroacetophenone and then chiral separat…
Preparation of α-methylbenzonitrile_Kain Industrial Additive
Background and overview[1] α-Methylbenzonitrile, also called 2-phenylpropionitrile, can be used to synthesize 2-phenylpropionic acid, which is widely used in the synthesis of medicines, spices and pes…
Preparation and application of 6,7-dihydro-4(5H)-benzofuranone_Kain Industrial Additive
Background and overview[1] 6,7-Dihydro-4(5H)-benzofuranone is an important pharmaceutical intermediate. It can be prepared by the reaction of 1,3-cyclohexanedione and chloroacetaldehyde aqueous soluti…
