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Preparation and application of ethyl 3-nitrophenyl acetate_Kain Industrial Additive
Background and overview[1] Ethyl 3-nitrophenylacetate can be used as a pharmaceutical synthesis intermediate. It can be prepared by the esterification reaction of 3-nitrophenylacetic acid and ethanol.…
Preparation and application of 1-bromo-3-fluoro-5-pyrrolidinebenzene_Kain Industrial Additive
Background and overview[1] 1-Bromo-3-fluoro-5-pyrrolidine benzene is a pharmaceutical intermediate, which can be prepared by nucleophilic substitution of 1-bromo-3,5-difluorobenzene and pyrrolidine. 1…
Application of ethyl 4-boron-3-chlorobenzoate_Kain Industrial Additives
Background and overview[1] Ethyl 4-boron-3-chlorobenzoate can be used as a pharmaceutical synthesis intermediate and applied in Suzuki coupling reaction. CN107207488 reports that ethyl 4-boron-3-chlor…
Preparation of 4,4′-bis(2-bromoacetyl)biphenyl_Kain Industrial Additive
Background and overview[1] 4,4’-Bis(2-bromoacetyl)biphenyl is a key intermediate in the synthesis of the anti-hepatitis C drug daclatasvir. Daclatasvir is a new hepatitis C drug developed by Bristol-M…
Preparation and application of 1-(3-bromophenyl)pyrrole_Kain Industrial Additive
Background and overview[1] 1-(3-Bromophenyl)pyrrole is an important pharmaceutical intermediate. For example, it can be used to prepare lithium 3-(pyrrolidin-1-yl)benzenesulfinate from 1,3-dibromobenz…
Preparation of 2-bromo-6-(trifluoromethoxy)benzoic acid_Kain Industrial Additive
Background and overview[1] 2-Bromo-6-(trifluoromethoxy)benzoic acid can be used as a pharmaceutical synthesis intermediate. It can use 2-amino-6-(trifluoromethyl)benzoic acid as the starting material …
Preparation of 5-bromobenzo[1,3]dioxole-4-carboxylic acid_Kain Industrial Additive
Background and overview[1] 5-Bromobenzo[1,3]dioxole-4-carboxylic acid can be used as a pharmaceutical synthesis intermediate. It can be prepared from 6-bromo-2,3-dihydroxybenzaldehyde in three steps. …
Synthesis of 5,6-dihydro-3-(4-morpholino-1-piperidinyl)phenyl]-2(1H)-pyridone_Kain Industrial Additive
Background and overview[1] 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidyl)phenyl]-2(1H)-pyridone is a One of the impurities in Pixaban. Apixaban is an oral, selective activated factor X inhibit…
Preparation and application of 3,4-dihydroxyphenylacetic acid methyl ester_Kain Industrial Additive
Background and overview[1] Methyl 3,4-dihydroxyphenylacetate can be used to prepare hydroxytyrosol. Hydroxytyrosol, whose chemical name is 3,4-Dihydroxyphenylethanol, is a hydroxyaromatic compound. Na…
Preparation and application of 2-hydroxy-5-trifluoromethylbenzoic acid_Kain Industrial Additive
Background and overview[1] 2-Hydroxy-5-trifluoromethylbenzoic acid is an organic intermediate that can be prepared by the reaction of 2-methoxy-5-(trifluoromethyl)benzoic acid and iodocyclohexane. Pre…
