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Synthesis of 5,6-dihydro-3-(4-morpholino-1-piperidinyl)phenyl]-2(1H)-pyridone_Kain Industrial Additive
Background and overview[1] 5,6-Dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidyl)phenyl]-2(1H)-pyridone is a One of the impurities in Pixaban. Apixaban is an oral, selective activated factor X inhibit…
Preparation and application of 3,4-dihydroxyphenylacetic acid methyl ester_Kain Industrial Additive
Background and overview[1] Methyl 3,4-dihydroxyphenylacetate can be used to prepare hydroxytyrosol. Hydroxytyrosol, whose chemical name is 3,4-Dihydroxyphenylethanol, is a hydroxyaromatic compound. Na…
Preparation and application of 2-hydroxy-5-trifluoromethylbenzoic acid_Kain Industrial Additive
Background and overview[1] 2-Hydroxy-5-trifluoromethylbenzoic acid is an organic intermediate that can be prepared by the reaction of 2-methoxy-5-(trifluoromethyl)benzoic acid and iodocyclohexane. Pre…
Preparation and application of 1-benzothiophene-3(2H)-one_Kain Industrial Additive
Background and overview[1] 1-Benzothiophene-3(2H)-one is an organic intermediate that can be prepared by reacting 2-carboxymethylthiobenzoic acid as a starting material. It can be used to prepare Fluo…
Preparation of 2-hydroxy-4,5-dimethoxyphenyl benzoate_Kain Industrial Additive
Background and overview[1] 2-Hydroxy-4,5-dimethoxybenzoic acid phenyl ester is an important intermediate in the synthesis of 2-aminothiazole compounds. 2-Aminothiazole compounds are an important class…
Preparation of 1-(4-hydroxyphenyl)piperazine dicyanobromide_Kain Industrial Additive
Overview[1] 1-(4-hydroxyphenyl)piperazine dicyanobromide can be used as a pharmaceutical synthesis intermediate, such as the preparation of 1-acetyl-4-(4-hydroxyphenyl)piperazine, ketoconazole (Ketoco…
Preparation of 2-[(4-chlorophenyl)(4-piperidinyloxy)methyl]pyridine_Kain Industrial Additive
Background and overview[1] 2-[(4-Chlorophenyl)(4-piperidinyloxy)methyl]pyridine is the key intermediate in the synthesis of bepotastine, 2-[(4-chlorophenyl)(4- Piperidinyloxy)methyl]pyridine is then s…
Preparation of 1-(4-fluorophenyl)-2-nitroethylene_Kain Industrial Additive
Background and overview[1] 1-(4-Fluorophenyl)-2-nitroethylene belongs to nitroalkenes, which are a class of biologically active compounds that are used in antibacterial, anticancer, antitumor or as ce…
Application of N,N,N’,N’-Tetramethyl-p-phenylenediamine dihydrochloride_Kain Industrial Additive
Background and overview[1][2] N,N,N’,N’-tetramethyl-p-phenylenediamine dihydrochloride, also called tetramethyl-p-phenylenediamine hydrochloride, or TMPD for short, is an oxidase reagent t…
Preparation and application of 4-iodo-2,6-dimethylaniline_Kain Industrial Additive
Background and overview[1] 4-Iodo-2,6-dimethylaniline is an organic intermediate that can be prepared from iodination of 2,6-dimethylaniline. The amino group of 4-iodo-2,6-dimethylaniline can be diazo…
